Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery

Author(s)
Zhang, Yunlong; Heller, Daniel A.; Dong, Yizhou; Chen, Delai; Gu, Zhen; ... Show more
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Abstract
Rationally designed siRNA delivery materials that are enabled by lipid-modified aminoglycosides are demonstrated. Leading materials identified are able to self-assemble with siRNA into well-defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo. Histology studies and liver function tests reveal that no apparent toxicity is caused by these nanoparticles at doses over two orders of magnitude.
Date issued
2013-09
URI
http://hdl.handle.net/1721.1/91256
Department
Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT
Journal
Advanced Materials
Publisher
Wiley-VCH Verlag GmbH & Co.
Citation
Zhang, Yunlong, Jeisa M. Pelet, Daniel A. Heller, Yizhou Dong, Delai Chen, Zhen Gu, Brian J. Joseph, Jasmine Wallas, and Daniel G. Anderson. “Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery.” Advanced Materials 25, no. 33 (June 27, 2013): 4641–4645.
Version: Author's final manuscript
ISSN
09359648
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