Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels

Author(s)
Heller, Daniel A.; Levi, Yair; Wallas, Jasmine; Pratt, George W.; Jiang, Shan; ... Show more
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Abstract
A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.
Date issued
2012-12
URI
http://hdl.handle.net/1721.1/91484
Department
Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT
Journal
Advanced Materials
Publisher
Wiley Blackwell
Citation
Heller, Daniel A., Yair Levi, Jeisa M. Pelet, Joshua C. Doloff, Jasmine Wallas, George W. Pratt, Shan Jiang, et al. “Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels.” Advanced Materials 25, no. 10 (December 27, 2012): 1449–1454.
Version: Author's final manuscript
ISSN
09359648
1521-4095
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