Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels
Author(s)Heller, Daniel A.; Levi, Yair; Pelet, Jeisa M.; Doloff, Joshua C.; Wallas, Jasmine; Pratt, George W.; Jiang, Shan; Sahay, Gaurav; Schroeder, Avi; Schroeder, Josh E.; Chyan, Yieu; Zurenko, Christopher; Querbes, William; Manzano, Miguel; Kohane, Daniel S.; Langer, Robert; Anderson, Daniel Griffith; ... Show more Show less
MetadataShow full item record
A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemical Engineering
Heller, Daniel A., Yair Levi, Jeisa M. Pelet, Joshua C. Doloff, Jasmine Wallas, George W. Pratt, Shan Jiang, et al. “Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels.” Advanced Materials 25, no. 10 (December 27, 2012): 1449–1454.
Author's final manuscript