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Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels

dc.contributor.authorHeller, Daniel A.
dc.contributor.authorLevi, Yair
dc.contributor.authorWallas, Jasmine
dc.contributor.authorPratt, George W.
dc.contributor.authorJiang, Shan
dc.contributor.authorSahay, Gaurav
dc.contributor.authorSchroeder, Josh E.
dc.contributor.authorChyan, Yieu
dc.contributor.authorZurenko, Christopher
dc.contributor.authorQuerbes, William
dc.contributor.authorManzano, Miguel
dc.contributor.authorKohane, Daniel S.
dc.contributor.authorAnderson, Daniel Griffith
dc.contributor.authorPelet, Jeisa
dc.contributor.authorDoloff, Joshua C
dc.contributor.authorSchroeder, Avraham Dror
dc.contributor.authorLanger, Robert S
dc.date.accessioned2014-11-07T13:31:27Z
dc.date.available2014-11-07T13:31:27Z
dc.date.issued2012-12
dc.date.submitted2012-10
dc.identifier.issn09359648
dc.identifier.issn1521-4095
dc.identifier.urihttp://hdl.handle.net/1721.1/91484
dc.description.abstractA new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (RO1 DE016516)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (R01 EB000244)en_US
dc.description.sponsorshipDamon Runyon Cancer Research Foundation (DFS-#2050-10)en_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/adma.201202881en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleModular ‘Click-in-Emulsion’ Bone-Targeted Nanogelsen_US
dc.typeArticleen_US
dc.identifier.citationHeller, Daniel A., Yair Levi, Jeisa M. Pelet, Joshua C. Doloff, Jasmine Wallas, George W. Pratt, Shan Jiang, et al. “Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels.” Advanced Materials 25, no. 10 (December 27, 2012): 1449–1454.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorHeller, Daniel A.en_US
dc.contributor.mitauthorLevi, Yairen_US
dc.contributor.mitauthorPelet, Jeisa M.en_US
dc.contributor.mitauthorDoloff, Joshua C.en_US
dc.contributor.mitauthorWallas, Jasmineen_US
dc.contributor.mitauthorPratt, George W.en_US
dc.contributor.mitauthorJiang, Shanen_US
dc.contributor.mitauthorSahay, Gauraven_US
dc.contributor.mitauthorSchroeder, Avien_US
dc.contributor.mitauthorChyan, Yieuen_US
dc.contributor.mitauthorManzano, Miguelen_US
dc.contributor.mitauthorLanger, Roberten_US
dc.contributor.mitauthorAnderson, Daniel Griffithen_US
dc.relation.journalAdvanced Materialsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsHeller, Daniel A.; Levi, Yair; Pelet, Jeisa M.; Doloff, Joshua C.; Wallas, Jasmine; Pratt, George W.; Jiang, Shan; Sahay, Gaurav; Schroeder, Avi; Schroeder, Josh E.; Chyan, Yieu; Zurenko, Christopher; Querbes, William; Manzano, Miguel; Kohane, Daniel S.; Langer, Robert; Anderson, Daniel G.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-2100-1171
dc.identifier.orcidhttps://orcid.org/0000-0001-5629-4798
dc.identifier.orcidhttps://orcid.org/0000-0002-4323-3264
dc.identifier.orcidhttps://orcid.org/0000-0003-4255-0492
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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