Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

Author(s)
Gianella, Anita; Mieszawska, Aneta J.; Hoeben, Freek J. M.; Janssen, Henk M.; Jarzyna, Peter A.; ... Show more
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Abstract
We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.
Date issued
2013-07
URI
http://hdl.handle.net/1721.1/91497
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemical Engineering
Journal
Chemical Communications
Publisher
Royal Society of Chemistry
Citation
Gianella, Anita, Aneta J. Mieszawska, Freek J. M. Hoeben, Henk M. Janssen, Peter A. Jarzyna, David P. Cormode, Kevin D. Costa, et al. “Synthesis and in Vitro Evaluation of a Multifunctional and Surface-Switchable Nanoemulsion Platform.” Chemical Communications 49, no. 82 (2013): 9392.
Version: Author's final manuscript
ISSN
1359-7345
1364-548X
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