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Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

dc.contributor.authorGianella, Anita
dc.contributor.authorMieszawska, Aneta J.
dc.contributor.authorHoeben, Freek J. M.
dc.contributor.authorJanssen, Henk M.
dc.contributor.authorJarzyna, Peter A.
dc.contributor.authorCormode, David P.
dc.contributor.authorCosta, Kevin D.
dc.contributor.authorRao, Satish
dc.contributor.authorFarokhzad, Omid C.
dc.contributor.authorLanger, Robert
dc.contributor.authorFayad, Zahi A.
dc.contributor.authorMulder, Willem J. M.
dc.date.accessioned2014-11-07T16:12:07Z
dc.date.available2014-11-07T16:12:07Z
dc.date.issued2013-07
dc.date.submitted2013-05
dc.identifier.issn1359-7345
dc.identifier.issn1364-548X
dc.identifier.urihttp://hdl.handle.net/1721.1/91497
dc.description.abstractWe present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.en_US
dc.description.sponsorshipNational Heart, Lung, and Blood Instituteen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Program of Excellence in Nanotechnology (PEN) Award Contract HHSN268201000045C)en_US
dc.language.isoen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/c3cc43618gen_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleSynthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platformen_US
dc.typeArticleen_US
dc.identifier.citationGianella, Anita, Aneta J. Mieszawska, Freek J. M. Hoeben, Henk M. Janssen, Peter A. Jarzyna, David P. Cormode, Kevin D. Costa, et al. “Synthesis and in Vitro Evaluation of a Multifunctional and Surface-Switchable Nanoemulsion Platform.” Chemical Communications 49, no. 82 (2013): 9392.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.mitauthorLanger, Roberten_US
dc.relation.journalChemical Communicationsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsGianella, Anita; Mieszawska, Aneta J.; Hoeben, Freek J. M.; Janssen, Henk M.; Jarzyna, Peter A.; Cormode, David P.; Costa, Kevin D.; Rao, Satish; Farokhzad, Omid C.; Langer, Robert; Fayad, Zahi A.; Mulder, Willem J. M.en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-4255-0492
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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