A Radical Role for TOR in Longevity
Author(s)Lamming, Dudley W.; Sabatini, David M.; Sabatini, David M.
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TOR (target of rapamycin) signaling regulates life span in many organisms, but the mechanism behind the effect is unknown. In this issue of Cell Metabolism, Pan and colleagues (2011) find that reduced TORC1 activity promotes yeast life span via a mechanism that, paradoxically, relies upon the production of normally deleterious reactive oxygen species.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Lamming, Dudley W., and David M. Sabatini. “A Radical Role for TOR in Longevity.” Cell Metabolism 13, no. 6 (June 2011): 617–618. © 2011 Elsevier Inc.
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