Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression
Author(s)DuPage, Michel J.; Mazumdar, Claire; Winslow, Monte M.; Bronson, Roderick T.; Crowley, Denise G.; Chen, Jianzhu; Cheung, Ann; Schmidt, Leah Marie; Jacks, Tyler E.; ... Show more Show less
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Neoantigens derived from somatic mutations in tumors may provide a critical link between the adaptive immune system and cancer. Here, we describe a system to introduce exogenous antigens into genetically engineered mouse lung cancers to mimic tumor neoantigens. We show that endogenous T cells respond to and infiltrate tumors, significantly delaying malignant progression. Despite continued antigen expression, T cell infiltration does not persist and tumors ultimately escape immune attack. Transplantation of cell lines derived from these lung tumors or prophylactic vaccination against the autochthonous tumors, however, results in rapid tumor eradication or selection of tumors that lose antigen expression. These results provide insight into the dynamic nature of the immune response to naturally arising tumors.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biology
DuPage, Michel, Ann F. Cheung, Claire Mazumdar, Monte M. Winslow, Roderick Bronson, Leah M. Schmidt, Denise Crowley, Jianzhu Chen, and Tyler Jacks. “Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression.” Cancer Cell 19, no. 1 (January 18, 2011): 72–85. © 2011 Elsevier Inc.
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