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dc.contributor.authorDuPage, Michel J.
dc.contributor.authorMazumdar, Claire
dc.contributor.authorWinslow, Monte M.
dc.contributor.authorBronson, Roderick T.
dc.contributor.authorCrowley, Denise G.
dc.contributor.authorChen, Jianzhu
dc.contributor.authorCheung, Ann
dc.contributor.authorSchmidt, Leah Marie
dc.contributor.authorJacks, Tyler E.
dc.date.accessioned2014-12-16T18:25:04Z
dc.date.available2014-12-16T18:25:04Z
dc.date.issued2011-01
dc.date.submitted2010-04
dc.identifier.issn15356108
dc.identifier.urihttp://hdl.handle.net/1721.1/92334
dc.description.abstractNeoantigens derived from somatic mutations in tumors may provide a critical link between the adaptive immune system and cancer. Here, we describe a system to introduce exogenous antigens into genetically engineered mouse lung cancers to mimic tumor neoantigens. We show that endogenous T cells respond to and infiltrate tumors, significantly delaying malignant progression. Despite continued antigen expression, T cell infiltration does not persist and tumors ultimately escape immune attack. Transplantation of cell lines derived from these lung tumors or prophylactic vaccination against the autochthonous tumors, however, results in rapid tumor eradication or selection of tumors that lose antigen expression. These results provide insight into the dynamic nature of the immune response to naturally arising tumors.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant 1 U54 CA126515-01)en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (Cancer Center Support (Core) Grant P30-CA14051)en_US
dc.description.sponsorshipJohn D. Proctor Foundation (Margaret A. Cunningham Immune Mechanisms in Cancer Research Fellowship Award)en_US
dc.description.sponsorshipDamon Runyon Cancer Research Foundation (Fellowship)en_US
dc.description.sponsorshipGenentech, Inc. (Postdoctoral Fellowship)en_US
dc.description.sponsorshipVirginia and D.K. Ludwig Fund for Cancer Researchen_US
dc.description.sponsorshipHoward Hughes Medical Instituteen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.ccr.2010.11.011en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceElsevieren_US
dc.titleEndogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progressionen_US
dc.typeArticleen_US
dc.identifier.citationDuPage, Michel, Ann F. Cheung, Claire Mazumdar, Monte M. Winslow, Roderick Bronson, Leah M. Schmidt, Denise Crowley, Jianzhu Chen, and Tyler Jacks. “Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression.” Cancer Cell 19, no. 1 (January 18, 2011): 72–85. © 2011 Elsevier Inc.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorDuPage, Michel J.en_US
dc.contributor.mitauthorCheung, Annen_US
dc.contributor.mitauthorMazumdar, Claireen_US
dc.contributor.mitauthorWinslow, Monte M.en_US
dc.contributor.mitauthorSchmidt, Leah Marieen_US
dc.contributor.mitauthorCrowley, Denise G.en_US
dc.contributor.mitauthorChen, Jianzhuen_US
dc.contributor.mitauthorJacks, Tyler E.en_US
dc.relation.journalCancer Cellen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsDuPage, Michel; Cheung, Ann F.; Mazumdar, Claire; Winslow, Monte M.; Bronson, Roderick; Schmidt, Leah M.; Crowley, Denise; Chen, Jianzhu; Jacks, Tyleren_US
dc.identifier.orcidhttps://orcid.org/0000-0001-5785-8911
dc.identifier.orcidhttps://orcid.org/0000-0002-5687-6154
dc.identifier.orcidhttps://orcid.org/0000-0001-9076-8475
dspace.mitauthor.errortrue
mit.licensePUBLISHER_POLICYen_US


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