The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP
Author(s)Govindarajan, Arvind; Israely, Inbal; Tonegawa, Susumu; Huang, Shu Ying
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The late-phase of long-term potentiation (L-LTP), the cellular correlate of long-term memory, induced at some synapses facilitates L-LTP expression at other synapses receiving stimulation too weak to induce L-LTP by itself. Using glutamate uncaging and two-photon imaging, we demonstrate that the efficacy of this facilitation decreases with increasing time between stimulations, increasing distance between stimulated spines and with the spines being on different dendritic branches. Paradoxically, stimulated spines compete for L-LTP expression if stimulated too closely together in time. Furthermore, the facilitation is temporally bidirectional but asymmetric. Additionally, L-LTP formation is itself biased toward occurring on spines within a branch. These data support the Clustered Plasticity Hypothesis, which states that such spatial and temporal limits lead to stable engram formation, preferentially at synapses clustered within dendritic branches rather than dispersed throughout the dendritic arbor. Thus, dendritic branches rather than individual synapses are the primary functional units for long-term memory storage.
DepartmentMassachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Picower Institute for Learning and Memory; RIKEN-MIT Center for Neural Circuit Genetics
Govindarajan, Arvind, Inbal Israely, Shu-Ying Huang, and Susumu Tonegawa. “The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP.” Neuron 69, no. 1 (January 2011): 132–146. © 2011 Elsevier Inc.
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