Palladium-Catalyzed Synthesis of N-Aryl Carbamates
Author(s)Fors, Brett P.; Vinogradova, Ekaterina; Park, Nathaniel Hamilton; Buchwald, Stephen Leffler
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An efficient synthesis of aryl carbamates was achieved by introducing alcohols into the reaction of palladium-catalyzed cross-coupling of ArX (X = Cl, OTf) with sodium cyanate. The use of aryl triflates as electrophilic components in this transformation allowed for an expanded substrate scope for direct synthesis of aryl isocyanates. This methodology provides direct access to major carbamate protecting groups, S-thiocarbamates, and diisocyanate precursors to polyurethane materials.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Vinogradova, Ekaterina V., Nathaniel H. Park, Brett P. Fors, and Stephen L. Buchwald. “Palladium-Catalyzed Synthesis of N -Aryl Carbamates.” Org. Lett. 15, no. 6 (March 15, 2013): 1394–1397.
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