| dc.contributor.author | McGowan, Meredeth A. | |
| dc.contributor.author | McAvoy, Camille Z. | |
| dc.contributor.author | Buchwald, Stephen Leffler | |
| dc.date.accessioned | 2015-02-11T15:56:25Z | |
| dc.date.available | 2015-02-11T15:56:25Z | |
| dc.date.issued | 2012-07 | |
| dc.date.submitted | 2012-06 | |
| dc.identifier.issn | 1523-7060 | |
| dc.identifier.issn | 1523-7052 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/94324 | |
| dc.description.abstract | A method for the Pd-catalyzed N-arylation of both aryl and alkyl amidines with a wide range of aryl bromides, chlorides, and triflates is described. The reactions proceed in short reaction times and with excellent selectivity for monoarylation. A one-pot synthesis of quinazoline derivatives, via addition of an aldehyde to the crude reaction mixture following Pd-catalyzed N-arylation, is also demonstrated. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant GM58160) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Postdoctoral Fellowship F32GM097771) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/ol301700y | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | PMC | en_US |
| dc.title | Palladium-Catalyzed N-Monoarylation of Amidines and a One-Pot Synthesis of Quinazoline Derivatives | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | McGowan, Meredeth A., Camille Z. McAvoy, and Stephen L. Buchwald. “Palladium-Catalyzed N-Monoarylation of Amidines and a One-Pot Synthesis of Quinazoline Derivatives.” Org. Lett. 14, no. 14 (July 20, 2012): 3800–3803. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Buchwald, Stephen Leffler | en_US |
| dc.contributor.mitauthor | McGowan, Meredeth A. | en_US |
| dc.contributor.mitauthor | McAvoy, Camille Z. | en_US |
| dc.relation.journal | Organic Letters | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | McGowan, Meredeth A.; McAvoy, Camille Z.; Buchwald, Stephen L. | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0003-3875-4775 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
