An Improved Catalyst System for the Pd-Catalyzed Fluorination of (Hetero)Aryl Triflates
Author(s)Lee, Hong Geun; Buchwald, Stephen Leffler; Milner, Phillip John
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The stable Pd(0) species [(1,5-cyclooctadiene)(L·Pd)[subscript 2]] (L = AdBrettPhos) has been prepared and successfully evaluated as a precatalyst for the fluorination of aryl triflates derived from biologically active and heteroaryl phenols, challenging substrates for our previously reported catalyst system. Additionally, this precatalyst activates at room temperature under neutral conditions, generates 1,5-cyclooctadiene as the only byproduct, and leads to overall cleaner reaction profiles.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Lee, Hong Geun, Phillip J. Milner, and Stephen L. Buchwald. “An Improved Catalyst System for the Pd-Catalyzed Fluorination of (Hetero)Aryl Triflates.” Org. Lett. 15, no. 21 (November 2013): 5602–5605.
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