Enantio- and Regioselective CuH-Catalyzed Hydroamination of Alkenes

Author(s)
Zhu, Shaolin; Niljianskul, Nootaree; Buchwald, Stephen Leffler
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Abstract
A highly enantio- and regioselective copper-catalyzed hydroamination reaction of alkenes has been developed using diethoxymethylsilane and esters of hydroxylamines. The process tolerates a wide variety of substituted styrenes, including trans-, cis-, and β,β-disubstituted styrenes, to yield α-branched amines. In addition, aliphatic alkenes coupled to generate exclusively the anti-Markovnikov hydroamination products.
Date issued
2013-10
URI
http://hdl.handle.net/1721.1/94499
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Zhu, Shaolin, Nootaree Niljianskul, and Stephen L. Buchwald. “Enantio- and Regioselective CuH-Catalyzed Hydroamination of Alkenes.” Journal of the American Chemical Society 135, no. 42 (October 23, 2013): 15746–15749.
Version: Author's final manuscript
ISSN
0002-7863
1520-5126
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