Enantio- and Regioselective CuH-Catalyzed Hydroamination of Alkenes
Author(s)Zhu, Shaolin; Niljianskul, Nootaree; Buchwald, Stephen Leffler
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A highly enantio- and regioselective copper-catalyzed hydroamination reaction of alkenes has been developed using diethoxymethylsilane and esters of hydroxylamines. The process tolerates a wide variety of substituted styrenes, including trans-, cis-, and β,β-disubstituted styrenes, to yield α-branched amines. In addition, aliphatic alkenes coupled to generate exclusively the anti-Markovnikov hydroamination products.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Journal of the American Chemical Society
American Chemical Society (ACS)
Zhu, Shaolin, Nootaree Niljianskul, and Stephen L. Buchwald. “Enantio- and Regioselective CuH-Catalyzed Hydroamination of Alkenes.” Journal of the American Chemical Society 135, no. 42 (October 23, 2013): 15746–15749.
Author's final manuscript