High Field Dynamic Nuclear Polarization NMR with Surfactant Sheltered Biradicals

Author(s)
Kiesewetter, Matthew K.; Michaelis, Vladimir K.; Walish, Joseph John; Griffin, Robert Guy; Swager, Timothy M
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Abstract
We illustrate the ability to place a water-insoluble biradical, bTbk, into a glycerol/water matrix with the assistance of a surfactant, sodium octyl sulfate (SOS). This surfactant approach enables a previously water insoluble biradical, bTbk, with favorable electron–electron dipolar coupling to be used for dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) experiments in frozen, glassy, aqueous media. Nuclear Overhauser enhancement (NOE) and paramagnetic relaxation enhancement (PRE) experiments are conducted to determine the distribution of urea and several biradicals within the SOS macromolecular assembly. We also demonstrate that SOS assemblies are an effective approach by which mixed biradicals are created through an assembly process.
Date issued
2014-02
URI
http://hdl.handle.net/1721.1/94614
Department
Massachusetts Institute of Technology. Department of Chemistry; Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology)
Journal
Journal of Physical Chemistry B
Publisher
American Chemical Society (ACS)
Citation
Kiesewetter, Matthew K., Vladimir K. Michaelis, Joseph J. Walish, Robert G. Griffin, and Timothy M. Swager. “High Field Dynamic Nuclear Polarization NMR with Surfactant Sheltered Biradicals.” The Journal of Physical Chemistry B 118, no. 7 (February 20, 2014): 1825–1830.
Version: Final published version
ISSN
1520-6106
1520-5207
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