Conjugation of vitamin E analog α-TOS to Pt(IV) complexes for dual-targeting anticancer therapy

Author(s)
Suntharalingam, Kogularamanan; Song, Ying; Lippard, Stephen J.
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Abstract
We report two platinum(IV) complexes conjugated with a vitamin E analog, α-tocopherol succinate (α-TOS). One of the conjugates displays the activity of both cisplatin and α-TOS in cancer cells, causing damage to DNA and mitochondria simultaneously. Accordingly, it serves as a promising dual-targeting anticancer agent.
Date issued
2013-12
URI
http://hdl.handle.net/1721.1/95497
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Chemical Communications
Publisher
Royal Society of Chemistry
Citation
Suntharalingam, Kogularamanan, Ying Song, and Stephen J. Lippard. “Conjugation of Vitamin E Analog α-TOS to Pt(IV) Complexes for Dual-Targeting Anticancer Therapy.” Chemical Communications 50, no. 19 (2014): 2465.
Version: Author's final manuscript
ISSN
1359-7345
1364-548X
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