| dc.contributor.author | Suntharalingam, Kogularamanan | |
| dc.contributor.author | Song, Ying | |
| dc.contributor.author | Lippard, Stephen J. | |
| dc.date.accessioned | 2015-02-24T20:40:01Z | |
| dc.date.available | 2015-02-24T20:40:01Z | |
| dc.date.issued | 2013-12 | |
| dc.date.submitted | 2013-11 | |
| dc.identifier.issn | 1359-7345 | |
| dc.identifier.issn | 1364-548X | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/95497 | |
| dc.description.abstract | We report two platinum(IV) complexes conjugated with a vitamin E analog, α-tocopherol succinate (α-TOS). One of the conjugates displays the activity of both cisplatin and α-TOS in cancer cells, causing damage to DNA and mitochondria simultaneously. Accordingly, it serves as a promising dual-targeting anticancer agent. | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Royal Society of Chemistry | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1039/c3cc48740g | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Conjugation of vitamin E analog α-TOS to Pt(IV) complexes for dual-targeting anticancer therapy | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Suntharalingam, Kogularamanan, Ying Song, and Stephen J. Lippard. “Conjugation of Vitamin E Analog α-TOS to Pt(IV) Complexes for Dual-Targeting Anticancer Therapy.” Chemical Communications 50, no. 19 (2014): 2465. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Lippard, Stephen J. | en_US |
| dc.contributor.mitauthor | Suntharalingam, Kogularamanan | en_US |
| dc.contributor.mitauthor | Song, Ying | en_US |
| dc.relation.journal | Chemical Communications | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Suntharalingam, Kogularamanan; Song, Ying; Lippard, Stephen J. | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-2693-4982 | |
| mit.license | OPEN_ACCESS_POLICY | en_US |
| mit.metadata.status | Complete | |
