Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold
Author(s)Lemon, Christopher M.; Curtin, Peter N.; Somers, Rebecca C.; Greytak, Andrew B.; Lanning, Ryan M.; Jain, Rakesh K.; Bawendi, Moungi G.; Nocera, Daniel G.; ... Show more Show less
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Acidity, hypoxia, and glucose levels characterize the tumor microenvironment rendering pH, pO2, and pGlucose, respectively, important indicators of tumor health. To this end, understanding how these parameters change can be a powerful tool for the development of novel and effective therapeutics. We have designed optical chemosensors that feature a quantum dot and an analyte-responsive dye. These noninvasive chemosensors permit pH, oxygen, and glucose to be monitored dynamically within the tumor microenvironment by using multiphoton imaging.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Lemon, Christopher M., Peter N. Curtin, Rebecca C. Somers, Andrew B. Greytak, Ryan M. Lanning, Rakesh K. Jain, Moungi G. Bawendi, and Daniel G. Nocera. “Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold.” Inorg. Chem. 53, no. 4 (February 17, 2014): 1900–1915.
Author's final manuscript