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dc.contributor.authorLemon, Christopher M.
dc.contributor.authorCurtin, Peter N.
dc.contributor.authorSomers, Rebecca C.
dc.contributor.authorGreytak, Andrew B.
dc.contributor.authorLanning, Ryan M.
dc.contributor.authorJain, Rakesh K.
dc.contributor.authorBawendi, Moungi G.
dc.contributor.authorNocera, Daniel G.
dc.date.accessioned2015-03-11T17:57:27Z
dc.date.available2015-03-11T17:57:27Z
dc.date.issued2013-10
dc.date.submitted2013-06
dc.identifier.issn0020-1669
dc.identifier.issn1520-510X
dc.identifier.urihttp://hdl.handle.net/1721.1/95953
dc.description.abstractAcidity, hypoxia, and glucose levels characterize the tumor microenvironment rendering pH, pO2, and pGlucose, respectively, important indicators of tumor health. To this end, understanding how these parameters change can be a powerful tool for the development of novel and effective therapeutics. We have designed optical chemosensors that feature a quantum dot and an analyte-responsive dye. These noninvasive chemosensors permit pH, oxygen, and glucose to be monitored dynamically within the tumor microenvironment by using multiphoton imaging.en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (Grant R01-CA126642)en_US
dc.language.isoen_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/ic401587ren_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleMetabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffolden_US
dc.typeArticleen_US
dc.identifier.citationLemon, Christopher M., Peter N. Curtin, Rebecca C. Somers, Andrew B. Greytak, Ryan M. Lanning, Rakesh K. Jain, Moungi G. Bawendi, and Daniel G. Nocera. “Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold.” Inorg. Chem. 53, no. 4 (February 17, 2014): 1900–1915.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorCurtin, Peter N.en_US
dc.contributor.mitauthorSomers, Rebecca C.en_US
dc.contributor.mitauthorGreytak, Andrew B.en_US
dc.contributor.mitauthorBawendi, Moungi G.en_US
dc.relation.journalInorganic Chemistryen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsLemon, Christopher M.; Curtin, Peter N.; Somers, Rebecca C.; Greytak, Andrew B.; Lanning, Ryan M.; Jain, Rakesh K.; Bawendi, Moungi G.; Nocera, Daniel G.en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-2220-4365
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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