ATP Consumption Promotes Cancer Metabolism
Author(s)Israelsen, William James; Vander Heiden, Matthew G.
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Cancer cells metabolize glucose by aerobic glycolysis, a phenomenon known as the Warburg effect. Fang et al. (2010) show that the endoplasmic reticulum enzyme ENTPD5 promotes ATP consumption and favors aerobic glycolysis. The findings suggest that nutrient uptake in cancer cells is limited by ATP and satisfies energy requirements other than ATP production.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biology
Israelsen, William J., and Matthew G. Vander Heiden. “ATP Consumption Promotes Cancer Metabolism.” Cell 143, no. 5 (November 2010): 669–671. © 2010 Elsevier Inc.
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