ATP Consumption Promotes Cancer Metabolism

Author(s)
Israelsen, William James; Vander Heiden, Matthew G.
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Abstract
Cancer cells metabolize glucose by aerobic glycolysis, a phenomenon known as the Warburg effect. Fang et al. (2010) show that the endoplasmic reticulum enzyme ENTPD5 promotes ATP consumption and favors aerobic glycolysis. The findings suggest that nutrient uptake in cancer cells is limited by ATP and satisfies energy requirements other than ATP production.
Date issued
2010-11
URI
http://hdl.handle.net/1721.1/96047
Department
Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Journal
Cell
Publisher
Elsevier
Citation
Israelsen, William J., and Matthew G. Vander Heiden. “ATP Consumption Promotes Cancer Metabolism.” Cell 143, no. 5 (November 2010): 669–671. © 2010 Elsevier Inc.
Version: Final published version
ISSN
00928674
1097-4172
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