ATP Consumption Promotes Cancer Metabolism
Author(s)
Israelsen, William James; Vander Heiden, Matthew G.
DownloadIsraelsen-2010-ATP Consumption Prom.pdf (272.6Kb)
PUBLISHER_POLICY
Publisher Policy
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Terms of use
Metadata
Show full item recordAbstract
Cancer cells metabolize glucose by aerobic glycolysis, a phenomenon known as the Warburg effect. Fang et al. (2010) show that the endoplasmic reticulum enzyme ENTPD5 promotes ATP consumption and favors aerobic glycolysis. The findings suggest that nutrient uptake in cancer cells is limited by ATP and satisfies energy requirements other than ATP production.
Date issued
2010-11Department
Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MITJournal
Cell
Publisher
Elsevier
Citation
Israelsen, William J., and Matthew G. Vander Heiden. “ATP Consumption Promotes Cancer Metabolism.” Cell 143, no. 5 (November 2010): 669–671. © 2010 Elsevier Inc.
Version: Final published version
ISSN
00928674
1097-4172