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Synthesis and Characterization of a Linear Dinitrosyl-Triiron Complex; Comparison to a Flavodiiron Nitric Oxide Reductase Intermediate

Author(s)
Victor, Eric; Minier, Mikael Antoine; Lippard, Stephen J.
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Alternative title
Synthesis and Characterization of a Linear Dinitrosyl-Triiron Complex
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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Abstract
Nitric oxide is released during the immune response by the host during bacterial infection. To counteract this response, bacteria have evolved nitric oxide reductases to convert NO to N[subscript 2]O. Some of these nitric oxide reductases contain a flavodiiron active site that has bridging carboxylates and hydroxides. Only a handful of synthetic complexes currently exist as models for the protein reactivity. Here, we report the reaction of [Fe[subscript 2](μ-OH)(μ-Ph[subscript 4]DBA)(TMEDA)[subscript 2](OTf)] (4) with NO(g) and Ph[subscript 3]CSNO to prepare the dinitrosyl-triiron complex [Fe[subscript 3](μ-OH)[subscript 2](μ-Ph[subscript 4]DBA)[subscript 2](TMEDA)[subscript 2](NO)[subscript 2]](OTf) (5). The reaction was monitored by UV/Vis and ReactIR spectroscopy, and compound 5 was characterized by X-ray crystallography, [superscript 57]Fe Mossbauer spectroscopy, Evan's method, and FTIR spectroscopy. The IR spectrum of compound 5 compares favorably to experimental spectroscopic data obtained for the proposed mononitrosylated intermediate of the protein.
Date issued
2014-06
URI
http://hdl.handle.net/1721.1/96248
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
European Journal of Inorganic Chemistry
Publisher
Wiley Blackwell
Citation
Victor, Eric, Mikael A. Minier, and Stephen J. Lippard. “Synthesis and Characterization of a Linear Dinitrosyl-Triiron Complex.” European Journal of Inorganic Chemistry 2014.33 (2014): 5640–5645.
Version: Author's final manuscript
ISSN
1434-1948
1099-0682

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