Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides
Author(s)Su, Mingjuan; Hoshiya, Naoyuki; Buchwald, Stephen Leffler
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An efficient method for the palladium-catalyzed amination of unprotected bromoimidazoles and bromopyrazoles is presented. The transformation is facilitated by the use of our newly developed Pd precatalyst based on the bulky biarylphosphine ligand tBuBrettPhos (L4). The mild reaction conditions employed allow for the preparation of a broad scope of aminoimidazoles and aminopyrazoles in moderate to excellent yields.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Su, Mingjuan, Naoyuki Hoshiya, and Stephen L. Buchwald. “Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides.” Org. Lett. 16, no. 3 (February 7, 2014): 832–835. © 2014 American Chemical Society
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