Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides
Author(s)Lee, Hong Geun; Milner, Phillip John; Buchwald, Stephen Leffler
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On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially with respect to nitrogen-containing heteroaryl bromides, and proceeds with minimal formation of the corresponding reduction products. A facilitated ligand modification process was shown to be critical to the success of the reaction.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Journal of the American Chemical Society
American Chemical Society (ACS)
Lee, Hong Geun, Phillip J. Milner, and Stephen L. Buchwald. “Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides.” Journal of the American Chemical Society 136, no. 10 (March 12, 2014): 3792–3795. © 2014 American Chemical Society.
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