Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein

Author(s)
Shatova, Tatyana A.; Lee, Jungkyu K.; Kaastrup, Kaja; Heimer, Brandon Walter; Sikes, Hadley
Thumbnail
DownloadHeimer-2014-Evaluating the sensitivity.pdf (705.6Kb)
PUBLISHER_CC
Terms of use
Metadata
Show full item record
Abstract
Hypermethylation of CpG islands in gene promoter regions has been shown to be a predictive biomarker for certain diseases. Most current methods for methylation profiling are not well-suited for clinical analysis. Here, we report the development of an inexpensive device and an epigenotyping assay with a format conducive to multiplexed analysis.
Date issued
2014-04
URI
http://hdl.handle.net/1721.1/96893
Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Journal
The Analyst
Publisher
Royal Society of Chemistry
Citation
Heimer, Brandon W., Tatyana A. Shatova, Jungkyu K. Lee, Kaja Kaastrup, and Hadley D. Sikes. “Evaluating the Sensitivity of Hybridization-Based Epigenotyping Using a Methyl Binding Domain Protein.” The Analyst 139, no. 15 (2014): 3695–3701. © 2015 Royal Society of Chemistry
Version: Final published version
ISSN
0003-2654
1364-5528
Collections