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Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein

dc.contributor.authorShatova, Tatyana A.
dc.contributor.authorLee, Jungkyu K.
dc.contributor.authorKaastrup, Kaja
dc.contributor.authorHeimer, Brandon Walter
dc.contributor.authorSikes, Hadley
dc.date.accessioned2015-05-04T14:45:16Z
dc.date.available2015-05-04T14:45:16Z
dc.date.issued2014-04
dc.date.submitted2014-04
dc.identifier.issn0003-2654
dc.identifier.issn1364-5528
dc.identifier.urihttp://hdl.handle.net/1721.1/96893
dc.description.abstractHypermethylation of CpG islands in gene promoter regions has been shown to be a predictive biomarker for certain diseases. Most current methods for methylation profiling are not well-suited for clinical analysis. Here, we report the development of an inexpensive device and an epigenotyping assay with a format conducive to multiplexed analysis.en_US
dc.description.sponsorshipDavid H. Koch Institute for Integrative Cancer Research at MIT (First-year Graduate Fellowship)en_US
dc.description.sponsorshipNational Science Foundation (U.S.). Graduate Research Fellowshipen_US
dc.description.sponsorshipBurroughs Wellcome Fund (Career Award at the Scientific Interface)en_US
dc.description.sponsorshipNational Institute of Environmental Health Sciences (Grant P30-ES002109)en_US
dc.description.sponsorshipMassachusetts Institute of Technology. James H. Ferry Fund for Innovation in Research Educationen_US
dc.language.isoen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/c4an00667den_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en_US
dc.sourceRoyal Society of Chemistryen_US
dc.titleEvaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain proteinen_US
dc.typeArticleen_US
dc.identifier.citationHeimer, Brandon W., Tatyana A. Shatova, Jungkyu K. Lee, Kaja Kaastrup, and Hadley D. Sikes. “Evaluating the Sensitivity of Hybridization-Based Epigenotyping Using a Methyl Binding Domain Protein.” The Analyst 139, no. 15 (2014): 3695–3701. © 2015 Royal Society of Chemistryen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.mitauthorHeimer, Brandon Walteren_US
dc.contributor.mitauthorShatova, Tatyana A.en_US
dc.contributor.mitauthorKaastrup, Kajaen_US
dc.contributor.mitauthorSikes, Hadleyen_US
dc.relation.journalThe Analysten_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsHeimer, Brandon W.; Shatova, Tatyana A.; Lee, Jungkyu K.; Kaastrup, Kaja; Sikes, Hadley D.en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1720-0183
dc.identifier.orcidhttps://orcid.org/0000-0002-7096-138X
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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