Critical Role of Smad and AP-1 Complexes in TGF-β-Dependent Apoptosis

Author(s)
Yamamura, Yasuko; Hua, Xianxin; Bergelson, Svetlana; Lodish, Harvey F
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Abstract
Transforming growth factor-β1 (TGF-β1) induces not only cell growth inhibition but also apoptosis in hepatocytes, myeloid cells, and epithelial cells. Smad complexes (Smad2-Smad4 and Smad3-Smad4) are identified as key signaling molecules which transmit TGF-β1 signal for growth inhibition from the TGF-β receptors to the nucleus (1, 2). However, their roles are unclear in the induction of apoptosis. Our results show here that both Smad and AP-1 complexes play a critical role in TGF-β1 signaling for apoptosis.
Date issued
2001
URI
http://hdl.handle.net/1721.1/97234
Department
Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Journal
The Scientific World JOURNAL
Publisher
Hindawi Publishing Corporation
Citation
Yamamura, Yasuko et al. “Critical Role of Smad and AP-1 Complexes in TGF-Β-Dependent Apoptosis.” The Scientific World JOURNAL 1 (2001): 96–96.
Version: Final published version
ISSN
1537-744X
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