| dc.contributor.author | Yamamura, Yasuko | |
| dc.contributor.author | Hua, Xianxin | |
| dc.contributor.author | Bergelson, Svetlana | |
| dc.contributor.author | Lodish, Harvey F | |
| dc.date.accessioned | 2015-06-09T13:37:50Z | |
| dc.date.available | 2015-06-09T13:37:50Z | |
| dc.date.issued | 2001 | |
| dc.identifier.issn | 1537-744X | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/97234 | |
| dc.description.abstract | Transforming growth factor-β1 (TGF-β1) induces not only cell growth inhibition but also apoptosis in hepatocytes, myeloid cells, and epithelial cells. Smad complexes (Smad2-Smad4 and Smad3-Smad4) are identified as key signaling molecules which
transmit TGF-β1 signal for growth inhibition from the TGF-β receptors to the nucleus (1, 2). However, their roles are unclear in the induction of apoptosis. Our results show here that both Smad and AP-1 complexes play a critical role in TGF-β1 signaling for apoptosis. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant CA63260) | en_US |
| dc.publisher | Hindawi Publishing Corporation | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1100/tsw.2001.201 | en_US |
| dc.rights | Creative Commons Attribution | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by/2.0 | en_US |
| dc.source | Hindawi Publishing Corporation | en_US |
| dc.title | Critical Role of Smad and AP-1 Complexes in TGF-β-Dependent Apoptosis | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Yamamura, Yasuko et al. “Critical Role of Smad and AP-1 Complexes in TGF-Β-Dependent Apoptosis.” The Scientific World JOURNAL 1 (2001): 96–96. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.department | Whitehead Institute for Biomedical Research | en_US |
| dc.contributor.mitauthor | Lodish, Harvey F. | en_US |
| dc.relation.journal | The Scientific World JOURNAL | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2015-06-06T07:01:01Z | |
| dc.language.rfc3066 | en | |
| dc.rights.holder | Copyright © 2001 Yasuko Yamamura et al. | |
| dspace.orderedauthors | Yamamura, Yasuko; Hua, Xianxin; Bergelson, Svetlana; Lodish, Harvey F. | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-7029-7415 | |
| mit.license | PUBLISHER_CC | en_US |
| mit.metadata.status | Complete | |
