Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion
Author(s)Shin, Yoojin; Kim, Hyunju; Han, Sewoon; Won, Jihee; Jeong, Hyo Eun; Lee, Eun-Sook; Kim, Jae-Hong; Chung, Seok; Kamm, Roger Dale; ... Show more Show less
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Plasticity and reciprocity of breast cancer cells to various extracellular matrice (ECMs) are three-dimensionally analyzed in quantitative way in a novel and powerful microfluidic in vitro platform. This successfully demonstrates the metastatic potential of cancer cells and their effective strategies of ECM proteolytic remodeling and morphological change, while interacting with other cells and invading into heterogeneous ECMs.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Mechanical Engineering
Advanced Healthcare Materials
Shin, Yoojin, Hyunju Kim, Sewoon Han, Jihee Won, Hyo Eun Jeong, Eun-Sook Lee, Roger D. Kamm, Jae-Hong Kim, and Seok Chung. “Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion.” Advanced Healthcare Materials 2, no. 6 (November 26, 2012): 790–794.
Author's final manuscript