Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep

Author(s)
Zheng, Shu; Goldblum, Rebecca R.; Gelwan, Noah A.; Ramos, Daniel M.; Nolan, Michael A.; ... Show more
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Abstract
Rapid eye movement (REM) sleep is an important component of the natural sleep/wake cycle, yet the mechanisms that regulate REM sleep remain incompletely understood. Cholinergic neurons in the mesopontine tegmentum have been implicated in REM sleep regulation, but lesions of this area have had varying effects on REM sleep. Therefore, this study aimed to clarify the role of cholinergic neurons in the pedunculopontine tegmentum (PPT) and laterodorsal tegmentum (LDT) in REM sleep generation. Selective optogenetic activation of cholinergic neurons in the PPT or LDT during non-REM (NREM) sleep increased the number of REM sleep episodes and did not change REM sleep episode duration. Activation of cholinergic neurons in the PPT or LDT during NREM sleep was sufficient to induce REM sleep.
Date issued
2015-01
URI
http://hdl.handle.net/1721.1/98021
Department
Institute for Medical Engineering and Science; Harvard University--MIT Division of Health Sciences and Technology; Lincoln Laboratory; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; McGovern Institute for Brain Research at MIT; Picower Institute for Learning and Memory
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Van Dort, Christa J., Daniel P. Zachs, Jonathan D. Kenny, Shu Zheng, Rebecca R. Goldblum, Noah A. Gelwan, Daniel M. Ramos, et al. “Optogenetic Activation of Cholinergic Neurons in the PPT or LDT Induces REM Sleep.” Proc Natl Acad Sci USA 112, no. 2 (December 29, 2014): 584–589.
Version: Final published version
ISSN
0027-8424
1091-6490
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