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Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep

dc.contributor.authorZheng, Shu
dc.contributor.authorGoldblum, Rebecca R.
dc.contributor.authorGelwan, Noah A.
dc.contributor.authorRamos, Daniel M.
dc.contributor.authorNolan, Michael A.
dc.contributor.authorWang, Karen
dc.contributor.authorWeng, Feng-Ju
dc.contributor.authorLin, Yingxi
dc.contributor.authorWilson, Matthew A.
dc.contributor.authorBrown, Emery N.
dc.contributor.authorVan Dort, Christa
dc.contributor.authorZachs, Daniel
dc.contributor.authorKenny, Jonathan Dillion
dc.date.accessioned2015-08-05T13:17:21Z
dc.date.available2015-08-05T13:17:21Z
dc.date.issued2015-01
dc.date.submitted2014-09
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/1721.1/98021
dc.description.abstractRapid eye movement (REM) sleep is an important component of the natural sleep/wake cycle, yet the mechanisms that regulate REM sleep remain incompletely understood. Cholinergic neurons in the mesopontine tegmentum have been implicated in REM sleep regulation, but lesions of this area have had varying effects on REM sleep. Therefore, this study aimed to clarify the role of cholinergic neurons in the pedunculopontine tegmentum (PPT) and laterodorsal tegmentum (LDT) in REM sleep generation. Selective optogenetic activation of cholinergic neurons in the PPT or LDT during non-REM (NREM) sleep increased the number of REM sleep episodes and did not change REM sleep episode duration. Activation of cholinergic neurons in the PPT or LDT during NREM sleep was sufficient to induce REM sleep.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant DP1-OD003646)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant TR01-GM104948)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant T32-HL07901)en_US
dc.description.sponsorshipMassachusetts General Hospital (Executive Committee on Research Fellowship)en_US
dc.description.sponsorshipMassachusetts General Hospital. Dept. of Anesthesia, Critical Care, and Pain Medicineen_US
dc.language.isoen_US
dc.publisherNational Academy of Sciences (U.S.)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1073/pnas.1423136112en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceNational Academy of Sciences (U.S.)en_US
dc.titleOptogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleepen_US
dc.typeArticleen_US
dc.identifier.citationVan Dort, Christa J., Daniel P. Zachs, Jonathan D. Kenny, Shu Zheng, Rebecca R. Goldblum, Noah A. Gelwan, Daniel M. Ramos, et al. “Optogenetic Activation of Cholinergic Neurons in the PPT or LDT Induces REM Sleep.” Proc Natl Acad Sci USA 112, no. 2 (December 29, 2014): 584–589.en_US
dc.contributor.departmentInstitute for Medical Engineering and Scienceen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentLincoln Laboratoryen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.departmentPicower Institute for Learning and Memoryen_US
dc.contributor.mitauthorVan Dort, Christaen_US
dc.contributor.mitauthorZachs, Danielen_US
dc.contributor.mitauthorKenny, Jonathan Dillionen_US
dc.contributor.mitauthorZheng, Shuen_US
dc.contributor.mitauthorGoldblum, Rebecca R.en_US
dc.contributor.mitauthorGelwan, Noah A.en_US
dc.contributor.mitauthorRamos, Daniel M.en_US
dc.contributor.mitauthorNolan, Michael A.en_US
dc.contributor.mitauthorWang, Karenen_US
dc.contributor.mitauthorWeng, Feng-Juen_US
dc.contributor.mitauthorLin, Yingxien_US
dc.contributor.mitauthorWilson, Matthew A.en_US
dc.contributor.mitauthorBrown, Emery N.en_US
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsVan Dort, Christa J.; Zachs, Daniel P.; Kenny, Jonathan D.; Zheng, Shu; Goldblum, Rebecca R.; Gelwan, Noah A.; Ramos, Daniel M.; Nolan, Michael A.; Wang, Karen; Weng, Feng-Ju; Lin, Yingxi; Wilson, Matthew A.; Brown, Emery N.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7002-1275
dc.identifier.orcidhttps://orcid.org/0000-0003-2668-7819
dc.identifier.orcidhttps://orcid.org/0000-0003-3745-3217
dc.identifier.orcidhttps://orcid.org/0000-0002-9615-3233
dc.identifier.orcidhttps://orcid.org/0000-0001-7149-3584
dc.identifier.orcidhttps://orcid.org/0000-0001-7734-6008
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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