dc.contributor.author | Seto, Jennifer E. | |
dc.contributor.author | Polat, Baris E. | |
dc.contributor.author | Blankschtein, Daniel | |
dc.contributor.author | Langer, Robert | |
dc.contributor.author | Lopez, Renata F. V. | |
dc.date.accessioned | 2015-10-13T18:31:34Z | |
dc.date.available | 2015-10-13T18:31:34Z | |
dc.date.issued | 2010-03 | |
dc.date.submitted | 2010-03 | |
dc.identifier.issn | 01683659 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/99232 | |
dc.description.abstract | The simultaneous application of ultrasound and the surfactant sodium lauryl sulfate (referred to as US/SLS) to skin enhances transdermal drug delivery (TDD) in a synergistic mechanical and chemical manner. Since full-thickness skin (FTS) and split-thickness skin (STS) differ in mechanical strength, US/SLS treatment may have different effects on their transdermal transport pathways. Therefore, we evaluated STS as an alternative to the well-established US/SLS-treated FTS model for TDD studies of hydrophilic permeants. We utilized the aqueous porous pathway model to compare the effects of US/SLS treatment on the skin permeability and the pore radius of pig and human FTS and STS over a range of skin electrical resistivity values. Our findings indicate that the US/SLS-treated pig skin models exhibit similar permeabilities and pore radii, but the human skin models do not. Furthermore, the US/SLS-enhanced delivery of gold nanoparticles and quantum dots (two model hydrophilic macromolecules) is greater through pig STS than through pig FTS, due to the presence of less dermis that acts as an artificial barrier to macromolecules. In spite of greater variability in correlations between STS permeability and resistivity, our findings strongly suggest the use of 700 μm-thick pig STS to investigate the in vitro US/SLS-enhanced delivery of hydrophilic macromolecules. | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Grant EB-00351) | en_US |
dc.description.sponsorship | Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies (Grant DAAD-19-02-D-002) | en_US |
dc.description.sponsorship | National Science Foundation (U.S.). Graduate Research Fellowship | en_US |
dc.description.sponsorship | Conselho Nacional de Pesquisas (Brazil) | en_US |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo | en_US |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1016/j.jconrel.2010.03.013 | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-NoDerivatives | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.source | PMC | en_US |
dc.title | Effects of ultrasound and sodium lauryl sulfate on the transdermal delivery of hydrophilic permeants: Comparative in vitro studies with full-thickness and split-thickness pig and human skin | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Seto, Jennifer E., Baris E. Polat, Renata F.V. Lopez, Daniel Blankschtein, and Robert Langer. “Effects of Ultrasound and Sodium Lauryl Sulfate on the Transdermal Delivery of Hydrophilic Permeants: Comparative in Vitro Studies with Full-Thickness and Split-Thickness Pig and Human Skin.” Journal of Controlled Release 145, no. 1 (July 1, 2010): 26–32. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
dc.contributor.mitauthor | Seto, Jennifer E. | en_US |
dc.contributor.mitauthor | Polat, Baris E. | en_US |
dc.contributor.mitauthor | Lopez, Renata F. V. | en_US |
dc.contributor.mitauthor | Blankschtein, Daniel | en_US |
dc.contributor.mitauthor | Langer, Robert | en_US |
dc.relation.journal | Journal of Controlled Release | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Seto, Jennifer E.; Polat, Baris E.; Lopez, Renata F.V.; Blankschtein, Daniel; Langer, Robert | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-7836-415X | |
dc.identifier.orcid | https://orcid.org/0000-0003-4255-0492 | |
mit.license | PUBLISHER_CC | en_US |
mit.metadata.status | Complete | |