Strategic use of nickel(0)-catalyzed enyne–epoxide reductive coupling toward the synthesis of (−)-cyatha-3,12-diene
Author(s)Sparling, Brian A.; Simpson, Graham L.; Jamison, Timothy F.
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Various situations are explored in which the nickel(0)-catalyzed enyne–epoxide reductive coupling was utilized to access key intermediates toward the total synthesis of (−)-cyatha-3,12-diene (1). Enantioenriched 3,5-dien-1-ols with a variety of functionality were obtained in a straightforward manner from easily accessible 1,3-enynes and terminal epoxides.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Sparling, Brian A., Graham L. Simpson, and Timothy F. Jamison. “Strategic Use of Nickel(0)-Catalyzed Enyne–epoxide Reductive Coupling Toward the Synthesis of (−)-Cyatha-3,12-Diene.” Tetrahedron 65, no. 16 (April 2009): 3270–3280.
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