Highly Selective Palladium-Catalyzed Cross-Coupling of Secondary Alkylzinc Reagents with Heteroaryl Halides
Author(s)Yang, Yang; Niedermann, Katrin; Han, Chong; Buchwald, Stephen Leffler
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The highly selective palladium-catalyzed Negishi coupling of secondary alkylzinc reagents with heteroaryl halides is described. The development of a series of biarylphosphine ligands has led to the identification of an improved catalyst for the coupling of electron-deficient heterocyclic substrates. Preparation and characterization of oxidative addition complex (L)(Ar)PdBr provided insight into the unique reactivity of catalysts based on CPhos-type ligands in facilitating challenging reductive elimination processes.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Yang, Yang, Katrin Niedermann, Chong Han, and Stephen L. Buchwald. “Highly Selective Palladium-Catalyzed Cross-Coupling of Secondary Alkylzinc Reagents with Heteroaryl Halides.” Organic Letters 16, no. 17 (September 5, 2014): 4638–4641. © 2014 American Chemical Society
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