Regioselective Synthesis of Benzimidazolones via Cascade C–N Coupling of Monosubstituted Ureas

Author(s)
Ernst, Johannes B.; Tay, Nicholas E. S.; Jui, Nathan T.; Buchwald, Stephen Leffler
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Abstract
A direct method for the regioselective construction of benzimidazolones is reported wherein a single palladium catalyst is employed to couple monosubstituted urea substrates with differentially substituted 1,2-dihaloaromatic systems. In this method, the catalyst is able to promote a cascade of two discrete chemoselective C–N bond-forming processes that allows the highly selective and predictable formation of complex heterocycles from simple, readily available starting materials.
Date issued
2014-06
URI
http://hdl.handle.net/1721.1/99671
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Ernst, Johannes B., Nicholas E. S. Tay, Nathan T. Jui, and Stephen L. Buchwald. “Regioselective Synthesis of Benzimidazolones via Cascade C–N Coupling of Monosubstituted Ureas.” Organic Letters 16, no. 14 (July 18, 2014): 3844–3846. © 2014 American Chemical Society
Version: Final published version
ISSN
1523-7060
1523-7052
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