Regioselective Synthesis of Benzimidazolones via Cascade C–N Coupling of Monosubstituted Ureas
Author(s)Ernst, Johannes B.; Tay, Nicholas E. S.; Jui, Nathan T.; Buchwald, Stephen Leffler
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A direct method for the regioselective construction of benzimidazolones is reported wherein a single palladium catalyst is employed to couple monosubstituted urea substrates with differentially substituted 1,2-dihaloaromatic systems. In this method, the catalyst is able to promote a cascade of two discrete chemoselective C–N bond-forming processes that allows the highly selective and predictable formation of complex heterocycles from simple, readily available starting materials.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Ernst, Johannes B., Nicholas E. S. Tay, Nathan T. Jui, and Stephen L. Buchwald. “Regioselective Synthesis of Benzimidazolones via Cascade C–N Coupling of Monosubstituted Ureas.” Organic Letters 16, no. 14 (July 18, 2014): 3844–3846. © 2014 American Chemical Society
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