MIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Disease Detection by Ultrasensitive Quantification of Microdosed Synthetic Urinary Biomarkers

Author(s)
Gaylord, Shonda T.; Ngan, Kevin C.; Dumont Milutinovic, Milena; Kwong, Gabriel A.; Bhatia, Sangeeta N.; Walt, David R.; Warren, Andrew David; ... Show more Show less
Thumbnail
DownloadBhatia_Disease detection.pdf (2.521Mb)
PUBLISHER_POLICY

Publisher Policy

Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.

Terms of use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Metadata
Show full item record
Abstract
The delivery of exogenous agents can enable noninvasive disease monitoring, but existing low-dose approaches require complex infrastructure. In this paper, we describe a microdose-scale injectable formulation of nanoparticles that interrogate the activity of thrombin, a key regulator of clotting, and produce urinary reporters of disease state. We establish a customized single molecule detection assay that enables urinary discrimination of thromboembolic disease in mice using doses of the nanoparticulate diagnostic agents that fall under regulatory guidelines for “microdosing.”
Date issued
2014-09
URI
http://hdl.handle.net/1721.1/99875
Department
Harvard University--MIT Division of Health Sciences and Technology
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Warren, Andrew D., Shonda T. Gaylord, Kevin C. Ngan, Milena Dumont Milutinovic, Gabriel A. Kwong, Sangeeta N. Bhatia, and David R. Walt. “Disease Detection by Ultrasensitive Quantification of Microdosed Synthetic Urinary Biomarkers.” Journal of the American Chemical Society 136, no. 39 (October 2014): 13709–13714. © 2014 American Chemical Society
Version: Final published version
ISSN
0002-7863
1520-5126

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries
PrivacyPermissionsAccessibilityContact us
MIT
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.