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dc.contributor.authorGaylord, Shonda T.
dc.contributor.authorNgan, Kevin C.
dc.contributor.authorDumont Milutinovic, Milena
dc.contributor.authorKwong, Gabriel A.
dc.contributor.authorBhatia, Sangeeta N.
dc.contributor.authorWalt, David R.
dc.contributor.authorWarren, Andrew David
dc.date.accessioned2015-11-10T15:08:02Z
dc.date.available2015-11-10T15:08:02Z
dc.date.issued2014-09
dc.date.submitted2014-06
dc.identifier.issn0002-7863
dc.identifier.issn1520-5126
dc.identifier.urihttp://hdl.handle.net/1721.1/99875
dc.description.abstractThe delivery of exogenous agents can enable noninvasive disease monitoring, but existing low-dose approaches require complex infrastructure. In this paper, we describe a microdose-scale injectable formulation of nanoparticles that interrogate the activity of thrombin, a key regulator of clotting, and produce urinary reporters of disease state. We establish a customized single molecule detection assay that enables urinary discrimination of thromboembolic disease in mice using doses of the nanoparticulate diagnostic agents that fall under regulatory guidelines for “microdosing.”en_US
dc.description.sponsorshipNational Science Foundation (U.S.). Graduate Research Fellowshipen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award F32CA159496-02)en_US
dc.description.sponsorshipBurroughs Wellcome Fund (Career Award at the Scientific Interface)en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (Koch Institute Support (Core) Grant P30-CA14051)en_US
dc.description.sponsorshipDavid H. Koch Institute for Integrative Cancer Research at MIT (Frontier Research Program)en_US
dc.language.isoen_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/ja505676hen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceACSen_US
dc.titleDisease Detection by Ultrasensitive Quantification of Microdosed Synthetic Urinary Biomarkersen_US
dc.typeArticleen_US
dc.identifier.citationWarren, Andrew D., Shonda T. Gaylord, Kevin C. Ngan, Milena Dumont Milutinovic, Gabriel A. Kwong, Sangeeta N. Bhatia, and David R. Walt. “Disease Detection by Ultrasensitive Quantification of Microdosed Synthetic Urinary Biomarkers.” Journal of the American Chemical Society 136, no. 39 (October 2014): 13709–13714. © 2014 American Chemical Societyen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.mitauthorWarren, Andrew Daviden_US
dc.contributor.mitauthorKwong, Gabriel A.en_US
dc.contributor.mitauthorBhatia, Sangeeta N.en_US
dc.relation.journalJournal of the American Chemical Societyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsWarren, Andrew D.; Gaylord, Shonda T.; Ngan, Kevin C.; Dumont Milutinovic, Milena; Kwong, Gabriel A.; Bhatia, Sangeeta N.; Walt, David R.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-1293-2097
dc.identifier.orcidhttps://orcid.org/0000-0003-1948-0289
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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