dc.contributor.author | Gaylord, Shonda T. | |
dc.contributor.author | Ngan, Kevin C. | |
dc.contributor.author | Dumont Milutinovic, Milena | |
dc.contributor.author | Kwong, Gabriel A. | |
dc.contributor.author | Bhatia, Sangeeta N. | |
dc.contributor.author | Walt, David R. | |
dc.contributor.author | Warren, Andrew David | |
dc.date.accessioned | 2015-11-10T15:08:02Z | |
dc.date.available | 2015-11-10T15:08:02Z | |
dc.date.issued | 2014-09 | |
dc.date.submitted | 2014-06 | |
dc.identifier.issn | 0002-7863 | |
dc.identifier.issn | 1520-5126 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/99875 | |
dc.description.abstract | The delivery of exogenous agents can enable noninvasive disease monitoring, but existing low-dose approaches require complex infrastructure. In this paper, we describe a microdose-scale injectable formulation of nanoparticles that interrogate the activity of thrombin, a key regulator of clotting, and produce urinary reporters of disease state. We establish a customized single molecule detection assay that enables urinary discrimination of thromboembolic disease in mice using doses of the nanoparticulate diagnostic agents that fall under regulatory guidelines for “microdosing.” | en_US |
dc.description.sponsorship | National Science Foundation (U.S.). Graduate Research Fellowship | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award F32CA159496-02) | en_US |
dc.description.sponsorship | Burroughs Wellcome Fund (Career Award at the Scientific Interface) | en_US |
dc.description.sponsorship | National Cancer Institute (U.S.) (Koch Institute Support (Core) Grant P30-CA14051) | en_US |
dc.description.sponsorship | David H. Koch Institute for Integrative Cancer Research at MIT (Frontier Research Program) | en_US |
dc.language.iso | en_US | |
dc.publisher | American Chemical Society (ACS) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1021/ja505676h | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | ACS | en_US |
dc.title | Disease Detection by Ultrasensitive Quantification of Microdosed Synthetic Urinary Biomarkers | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Warren, Andrew D., Shonda T. Gaylord, Kevin C. Ngan, Milena Dumont Milutinovic, Gabriel A. Kwong, Sangeeta N. Bhatia, and David R. Walt. “Disease Detection by Ultrasensitive Quantification of Microdosed Synthetic Urinary Biomarkers.” Journal of the American Chemical Society 136, no. 39 (October 2014): 13709–13714. © 2014 American Chemical Society | en_US |
dc.contributor.department | Harvard University--MIT Division of Health Sciences and Technology | en_US |
dc.contributor.mitauthor | Warren, Andrew David | en_US |
dc.contributor.mitauthor | Kwong, Gabriel A. | en_US |
dc.contributor.mitauthor | Bhatia, Sangeeta N. | en_US |
dc.relation.journal | Journal of the American Chemical Society | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Warren, Andrew D.; Gaylord, Shonda T.; Ngan, Kevin C.; Dumont Milutinovic, Milena; Kwong, Gabriel A.; Bhatia, Sangeeta N.; Walt, David R. | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-1293-2097 | |
dc.identifier.orcid | https://orcid.org/0000-0003-1948-0289 | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |