Lecture 19

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Microtubules

Filaments in the Cycloskeleton; Major Types:
- Actin Filaments
- Intermediate Filaments
- Microtubules
Microtubule Structure:
- Tubulin Subunits
- Protofilaments, Nucleation and Growth
- Polarity
Dynamic Instability:
- Dogterom, Marileen, and Stanislas Leibler. "Physical Aspects of the Growth and Regulation of Microtubule Structures." Physics Review Letters 70, no. 9 (March 1, 1993): 1347.
- Flyvbjerg, Henrik, Timothy E. Holy, and Stanislas Leibler. "Stochastic Dynamics of Microtubules: A Model for Caps and Catastrophes." Physics Review Letters 73, no. 17 (October 24, 1994): 2372.
- Lecture Notes: Page 1 (GIF), Page 2 (GIF), Page 3 (GIF), Page 4 (GIF)
Search Strategy:
- Mitosis
- Condensation of RecA on ssDNA as a Tool for Computation by Stochastic Assembly
- Kinetic Proof-reading
  - Fidelity of Replication (Hopfield 74)
  - Recognition by T Cells
Self-organization of Microtubules and Motors in Vitro