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Lecture 4 and 5

Lectures: 1 | 2 | 3 | 4-5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 15 | 16 | 17 | 19 | 20 | 21 | 22 | 23 | 26

Probability of Fixation and Sequence Comparison

  1. Probability of Fixation
    • Population of N diploids, Selection s and Mutation Rate m.
  2. Biological Implications of the Steady State Solution and Probability of Fixation
    • Heterozygosity of Human Population
    • Fixation of Neutral, Deleterious and Advantageous Mutations
  3. Sequence Comparison
    • Protein Sequences (JPG): Amino Acids and their Properties
    • Why do we need to compare sequences?
      • Find Dissimilarities
      • Similar Sequences = Similar Properties
      • Similar Sequences = Common Ancestral Gene
    • Mutations -> Gapless Alignments
    • Mutations, Insertions and Deletions -> Gapped Alignment
  4. Sequence Alignments
  5. Algorithms for Sequence Alignments
    • Dynamics Programming
    • Example
    • Global and Local Alignments
  6. Substitution Matrices
  7. BLAST
    • How it Works
    • Examples