Lecture 20

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Molecular Motors

Molecular Motors:
- Kinesin Structure
- Dyenin and Kinesin Move in Opposite Directions along Microtubules
- Myosin Moves on Action Filaments
- Animation of Motion of Kinesin on a Microtubule (MOV)
General Scheme of Motor Transport with the Consumption of ATP (Page 1 (GIF) of Lecture Notes)
Motion in a Noisy Environment:

Motion in a noisy environment.

Feynman's Ratchet and Pawl
Simulation of a Brownian Motor
From the Web page of George Oster:
- Wang, H., and G. Oster. "Ratchets, Power Strokes, and Molecular Motors." Appl. Phys. A 75, no. 315 (2002). (PDF)
- Bustamante, C., D. Keller, and G. Oster. "The Physics of Molecular Motors." Acc. Chem. Res. 34, no. 412 (2001). (PDF)
- Animation of Energy Landscape for a Rotary Motor

Asymmetric Hopping Models:
- Fisher, M. E., and A. B. Kolomeisky. "The Force Exerted by a Molecular Motor." PNAS 96, no. 6597 (1999).
- Multiple Internal States
- Solution with One Internal State (Page 2 (GIF) of Lecture Notes)
- Einstein Force, Stalling Force (Page 3 (GIF) of Lecture Notes)
Capturing and Viewing Single Molecules:
- Optical Tweezers
- Fluorescent Light Microscopy
- Actin-myosin Movies by Albrecht Ott
Theory of Brownian Motion (Lecture Notes (PDF))