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Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer
Author(s)
Sivanand, Sharanya; Vander Heiden, Matthew G
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© 2020 Elsevier Inc. Metabolic pathways must be adapted to support cell processes required for transformation and cancer progression. Amino acid metabolism is deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affecting cancer cell state as well as systemic metabolism in individuals with malignancy. This review highlights key concepts surrounding the current understanding of branched-chain amino acid metabolism and its role in cancer.
Date issued
2020Journal
Cancer Cell
Publisher
Elsevier BV