Notice

This is not the latest version of this item. The latest version can be found at:https://dspace.mit.edu/handle/1721.1/135273.2

Show simple item record

A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density

dc.contributor.authorSinnott-Armstrong, N
dc.contributor.authorSousa, IS
dc.contributor.authorLaber, S
dc.contributor.authorRendina-Ruedy, E
dc.contributor.authorNitter Dankel, SE
dc.contributor.authorFerreira, T
dc.contributor.authorMellgren, G
dc.contributor.authorKarasik, D
dc.contributor.authorRivas, M
dc.contributor.authorPritchard, J
dc.contributor.authorGuntur, AR
dc.contributor.authorCox, RD
dc.contributor.authorLindgren, CM
dc.contributor.authorHauner, H
dc.contributor.authorSallari, R
dc.contributor.authorRosen, CJ
dc.contributor.authorHsu, YH
dc.contributor.authorLander, ES
dc.contributor.authorKiel, DP
dc.contributor.authorClaussnitzer, M
dc.date.accessioned2021-10-27T20:22:44Z
dc.date.available2021-10-27T20:22:44Z
dc.date.issued2021-03-02
dc.identifier.urihttps://hdl.handle.net/1721.1/135273
dc.description.abstractNasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation for the perplexing finding that individuals with T2D have higher BMD but greater susceptibility to bone fracture.
dc.language.isoen
dc.publisherElsevier BV
dc.relation.isversionof10.1016/j.cmet.2021.01.001
dc.rightsCreative Commons Attribution 4.0 International license
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceElsevier
dc.titleA regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density
dc.typeArticle
dc.relation.journalCell Metabolism
dc.eprint.versionFinal published version
dc.type.urihttp://purl.org/eprint/type/JournalArticle
eprint.statushttp://purl.org/eprint/status/PeerReviewed
dc.date.updated2021-07-20T18:04:37Z
dspace.orderedauthorsSinnott-Armstrong, N; Sousa, IS; Laber, S; Rendina-Ruedy, E; Nitter Dankel, SE; Ferreira, T; Mellgren, G; Karasik, D; Rivas, M; Pritchard, J; Guntur, AR; Cox, RD; Lindgren, CM; Hauner, H; Sallari, R; Rosen, CJ; Hsu, YH; Lander, ES; Kiel, DP; Claussnitzer, M
dspace.date.submission2021-07-20T18:04:39Z
mit.journal.volume33
mit.journal.issue3
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work Needed


Files in this item

Thumbnail
Name:
1-s2.0-S1550413121000012-main.pdf
Size:
3.206Mb
Format:
PDF
Description:
Published version
View/Open

This item appears in the following Collection(s)

Show simple item record

Version History

VersionItemDateSummary
21721.1/135273.22022-04-04T19:53:14ZPublication information verified/added.
11721.1/135273*2021-10-27T20:22:44Z

*Selected version