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A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density

Author(s)
Sinnott-Armstrong, N; Sousa, IS; Laber, S; Rendina-Ruedy, E; Nitter Dankel, SE; ... Show more
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Abstract
Nasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation for the perplexing finding that individuals with T2D have higher BMD but greater susceptibility to bone fracture.
Date issued
2021-03-02
URI
https://hdl.handle.net/1721.1/135273
Journal
Cell Metabolism
Publisher
Elsevier BV
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21721.1/135273.22022-04-04T19:53:14ZPublication information verified/added.
11721.1/135273*2021-10-27T20:22:44Z

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