Notice
This is not the latest version of this item. The latest version can be found at:https://dspace.mit.edu/handle/1721.1/140333.2
Amphiphilic Biaryl Monophosphine Ligands by Regioselective Sulfonation
DownloadAccepted version (943.5Kb)
Open Access Policy
Open Access Policy
Creative Commons Attribution-Noncommercial-Share Alike
Terms of use
Metadata
Show full item recordAbstract
© 2021 American Chemical Society. Amphiphilic ligands are valued for their ability to facilitate organometallic reactions in the presence of water. The regioselective sulfonation of a series of commercially available biaryl monophosphines to generate amphiphilic ligands is presented. In this one-step protocol, the temperature and addition of fuming sulfuric acid were carefully controlled to arrive at sulfonated biaryl monophosphine ligands in high yields with >95% regioselectivity without the need for chromatographic purification.
Date issued
2021Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Rodriguez, Jacob, Dhanjee, Heemal H and Buchwald, Stephen L. 2021. "Amphiphilic Biaryl Monophosphine Ligands by Regioselective Sulfonation." Organic Letters, 23 (3).
Version: Author's final manuscript