Browsing MIT Open Access Articles by Title
Now showing items 29727-29746 of 55846
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A mechanistic model for drug release in PLGA biodegradable stent coatings coupled with polymer degradation and erosion
(John Wiley & Sons, Inc., 2015-05)Biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) coating for applications in drug-eluting stents has been receiving increasing interest as a result of its unique properties compared with biodurable polymers in ... -
Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells
(Elsevier BV, 2021-06)Manufacturing of recombinant adeno-associated virus (rAAV) viral vectors remains challenging, with low yields and low full:empty capsid ratios in the harvest. To elucidate the dynamics of recombinant viral production, we ... -
Mechanistic Model for Production of Recombinant Adeno-associated Virus via Triple Transfection of HEK293 Cells
(Elsevier BV, 2021)Manufacturing of recombinant adeno-associated virus (rAAV) viral vectors remains challenging, with low yields and low full:empty capsid ratios in the harvest. To elucidate the dynamics of recombinant viral production, we ... -
A Mechanistic Model of Macromolecular Allocation, Elemental Stoichiometry, and Growth Rate in Phytoplankton
(Frontiers Media SA, 2020-02)We present a model of the growth rate and elemental stoichiometry of phytoplankton as a function of resource allocation between and within broad macromolecular pools under a variety of resource supply conditions. The model ... -
Mechanistic modeling of viral particle production
(Wiley, 2022-12-03)Viral systems such as wild-type viruses, viral vectors, and virus-like particles are essential components of modern biotechnology and medicine. Despite their importance, the commercial-scale production of viral systems ... -
Mechanistic origins of bombardier beetle (Brachinini) explosion-induced defensive spray pulsation
(American Association for the Advancement of Science (AAAS), 2015-04)Bombardier beetles (Brachinini) use a rapid series of discrete explosions inside their pygidial gland reaction chambers to produce a hot, pulsed, quinone-based defensive spray. The mechanism of brachinines’ spray pulsation ... -
Mechanistic Studies Lead to Dramatically Improved Reaction Conditions for the Cu-Catalyzed Asymmetric Hydroamination of Olefins
(American Chemical Society (ACS), 2015-11)Enantioselective copper(I) hydride (CuH)-catalyzed hydroamination has undergone significant development over the past several years. To gain a general understanding of the factors governing these reactions, kinetic and ... -
Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction
(Nature Publishing Group, 2013-04)(S)-2-hydroxypropylphosphonate ((S)-2-HPP) epoxidase (HppE) is a mononuclear non-haem-iron-dependent enzyme1, 2, 3 responsible for the final step in the biosynthesis of the clinically useful antibiotic fosfomycin4. Enzymes ... -
Mechanistic studies of Gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cells
(BioMed Central Ltd., 2012-09)Background: Pancreatic cancer remains the deadliest of all cancers, with a mortality rate of 91%. Gemcitabine is considered the gold chemotherapeutic standard, but only marginally improves life-span due to its chemical ... -
Mechanistic Studies of Reactions of Peroxodiiron(III) Intermediates in T201 Variants of Toluene/o-Xylene Monooxygenase Hydroxylase
(American Chemical Society, 2011-05)Site-directed mutagenesis studies of a strictly conserved T201 residue in the active site of toluene/o-xylene monooxygenase hydroxylase (ToMOH) revealed that a single mutation can facilitate kinetic isolation of two ... -
Mechanistic studies of the anticancer activity of an octahedral hexanuclear Pt(II) cage
(Elsevier, 2016-03)The cellular response evoked by a hexanuclear platinum complex, Pt6L4(1), is reported. Compound 1, a 3-nm octahedral cage formed by self-assembly of six Pt(II) centers and four 2,4,6-tris(4-pyridyl)-1,3,5-triazine ligands ... -
Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage
(Oxford University Press (OUP), 2008-05)The bleomycins (BLMs) are a family of natural glycopeptides used clinically as antitumor agents. In the presence of required cofactors (Fe[superscript 2+] and O[subscript 2]), BLM causes both single-stranded (ss) and ... -
Mechanistic Studies on the Copper-Catalyzed N-Arylation of Amides
(American Chemical Society (ACS), 2008-12)The copper-catalyzed N-arylation of amides, i.e., the Goldberg reaction, is an efficient method for the construction of products relevant to both industry and academic settings. Herein, we present mechanistic details ... -
Mechanistic study of the formation of ring-retaining and ring-opening products from the oxidation of aromatic compounds under urban atmospheric conditions
(Copernicus GmbH, 2019-12)Aromatic hydrocarbons make up a large fraction of anthropogenic volatile organic compounds and contribute significantly to the production of tropospheric ozone and secondary organic aerosol (SOA). Four toluene and four ... -
Mechanistic understanding and strategies to design interfaces of solid electrolytes: insights gained from transmission electron microscopy
(Springer US, 2019-05-01)Abstract Solid electrolytes (SEs) have gained increased attention for their promise to enable higher volumetric energy density and enhanced safety required for future battery systems. SEs are not only a key ... -
Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics
(Nature Publishing Group, 2017-10)In vitro incubation of nanomaterials with plasma offer insights on biological interactions, but cannot fully explain the in vivo fate of nanomaterials. Here, we use a library of polymer nanoparticles to show how physicochemical ... -
Mechanistically Guided Design of Ligands That Significantly Improve the Efficiency of CuH-Catalyzed Hydroamination Reactions
(American Chemical Society (ACS), 2018-09)Using a mechanically guided ligand design approach, a new ligand (SEGFAST) for the CuH-catalyzed hydroamination reaction of unactivated terminal olefins has been developed, providing a 62-fold rate increase over reactions ... -
Mechano-Chemical Effect of Gelatin- and HA-Based Hydrogels on Human Retinal Progenitor Cells
(Multidisciplinary Digital Publishing Institute, 2023-01-11)Engineering matrices for cell therapy requires design criteria that include the ability of these materials to support, protect and enhance cellular behavior in vivo. The chemical and mechanical formulation of the biomaterials ... -
Mechano-genomic regulation of coronaviruses and its interplay with ageing
(Springer Science and Business Media LLC, 2020-04)Coronaviruses employ various nuclear signalling mechanisms for their propagation. Here we link replication of coronaviruses, including SARS-CoV-2, the coronavirus disease 2019 (COVID-19)-causing virus, with cytoskeleton-dependent ... -
Mechanobiological model for simulation of injured cartilage degradation via pro-inflammatory cytokines and mechanical stimulus
(Public Library of Science (PLoS), 2020)© 2020 Eskelinen et al. Post-traumatic osteoarthritis (PTOA) is associated with cartilage degradation, ultimately leading to disability and decrease of quality of life. Two key mechanisms have been suggested to occur in ...
