Browsing MIT Open Access Articles by Subject "Immunology"
Now showing items 1-9 of 9
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Casting a wider net: Immunosurveillance by nonclassical MHC molecules
(Public Library of Science (PLoS), 2019-02-21)Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological ... -
Funding: Interdisciplinary challenges
(Springer Science and Business Media LLC, 2016-07-26)Scientific analysis of funding support suggests that interdisciplinary research proposals are less successful than those focused on single disciplines. This has negative implications for the development of interdisciplinary ... -
Gamma-glutamyltranspeptidase expression by Helicobacter saguini, an enterohepatic Helicobacter species isolated from cotton top tamarins with chronic colitis
(Wiley, 2018-11-14)Background: Helicobacter saguini is a novel enterohepatic Helicobacter species isolated from captive cotton top tamarins with chronic colitis and colon cancer. Monoassociated H. saguini infection in gnotobiotic IL-10 −/− ... -
Generation of bispecific antibodies by structure-guided redesign of IgG constant regions
(Frontiers Media SA, 2023-01-10)<jats:p>Bispecific antibodies (BsAbs) form an exciting class of bio-therapeutics owing to their multispecificity. Although numerous formats have been developed, generation of hetero-tetrameric IgG1-like BsAbs having ... -
Large-scale antibody immune response mapping of splenic B cells and bone marrow plasma cells in a transgenic mouse model
(Frontiers Media SA, 2023-06-05)Molecular characterization of antibody immunity and human antibody discovery is mainly carried out using peripheral memory B cells, and occasionally plasmablasts, that express B cell receptors (BCRs) on their cell surface. ... -
Megakaryocytes respond during sepsis and display innate immune cell behaviors
(Frontiers Media SA, 2023-03-02)Megakaryocytes (MKs) are precursors to platelets, the second most abundant cells in the peripheral circulation. However, while platelets are known to participate in immune responses and play significant functions during ... -
Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance
(Rockefeller University Press, 2019-10-24)Foxp3+ regulatory T (T reg) cells are pivotal regulators of immune tolerance, with T cell receptor (TCR)-driven activated T reg (aT reg) cells playing a central role; yet how TCR signaling propagates to control aT reg cell ... -
A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta
(Frontiers Media SA, 2023-03-09)<jats:p>Licensed COVID-19 vaccines ameliorate viral infection by inducing production of neutralizing antibodies that bind the SARS-CoV-2 Spike protein and inhibit viral cellular entry. However, the clinical effectiveness ... -
A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion
(Elsevier BV, 2018-07)Pancreatic adenocarcinoma (PDAC) is mostly refractory to immunotherapies. In this issue of Immunity, Li et al. (2018) generate a library of clonal PDAC tumors to examine the tumor-intrinsic features shaping the anti-tumor ...