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Mechanisms and models of somatic cell reprogramming
(Nature Publishing Group, 2013-05)
Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells
(Elsevier, 2010-08)
Knowledge of both the global chromatin structure and the gene expression programs of human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) should provide a robust means to assess whether the genomes ...
X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner
(National Academy of Sciences (U.S.), 2012-07)
Embryogenesis requires the timely and coordinated activation of developmental regulators. It has been suggested that the recently discovered class of histone demethylases (UTX and JMJD3) that specifically target the ...
Direct Reprogramming of Fibroblasts into Embryonic Sertoli-like Cells by Defined Factors
(Elsevier, 2012-09)
Sertoli cells are considered the “supporting cells” of the testis that play an essential role in sex determination during embryogenesis and in spermatogenesis during adulthood. Their essential roles in male fertility along ...
Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells
(Elsevier, 2014-11)
Overexpression of transcription factors has been used to directly reprogram somatic cells into a range of other differentiated cell types, including multipotent neural stem cells (NSCs), that can be used to generate neurons ...
Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs
(Elsevier BV, 2019-04)
Expansion of transposable elements (TEs) coincides with evolutionary shifts in gene expression. TEs frequently harbor binding sites for transcriptional regulators, thus enabling coordinated genome-wide activation of species- ...
Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus
(Nature Publishing Group, 2013-10)
Influenza A virus-specific B lymphocytes and the antibodies they produce protect against infection. However, the outcome of interactions between an influenza haemagglutinin-specific B cell via its receptor (BCR) and virus ...
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4
(United States National Academy of Sciences, 2009-04)
Ectopic expression of defined transcription factors can reprogram somatic cells to induced pluripotent stem (iPS) cells, but the utility of iPS cells is hampered by the use of viral delivery systems. Small molecules offer ...
Transgene Excision Has No Impact on In Vivo Integration of Human iPS Derived Neural Precursors
(Public Library of Science, 2011-09)
The derivation of induced human pluripotent stem cells (hiPS) has generated significant enthusiasm particularly for the prospects of cell-based therapy. But there are concerns about the suitability of iPS cells for in vivo ...
Technical Challenges in Using Human Induced Pluripotent Stem Cells to Model Disease
(Elsevier, 2009-12)
Reprogramming of human somatic cells uses readily accessible tissue, such as skin or blood, to generate embryonic-like induced pluripotent stem cells (iPSCs). This procedure has been applied to somatic cells from patients ...