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In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration

Author(s)
Sangaré, Lamba Omar; Ólafsson, Einar B; Wang, Yifan; Yang, Ninghan; Julien, Lindsay; ... Show more
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Abstract
© 2019 Elsevier Inc. Sangaré et al. use a CRISPR screen to determine the in vivo fitness of Toxoplasma genes. They identify a secreted protein, TgWIP, which determines dendritic cell motility and transmigration in the infected host. In mice, TgWIP determines T. gondii dissemination from the site of infection to distant organs.
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https://hdl.handle.net/1721.1/132590
Journal
Cell Host and Microbe
Publisher
Elsevier BV
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21721.1/132590.22022-05-16T19:45:28ZPublication information verified/added.
11721.1/132590*2021-09-20T18:23:13Z

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