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Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator
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© 2020 Elsevier Inc. One-photon fluorescent imaging of calcium signals can capture the activity of hundreds of neurons across large fields of view but suffers from crosstalk from neuropil. Shemesh et al. engineer cell-body-targeted variants of fluorescent calcium indicators and show in mice and zebrafish that artifactual spikes and correlations are greatly reduced.
Date issued
2020Journal
Neuron
Publisher
Elsevier BV