Browsing MIT Open Access Articles by Title
Now showing items 56207-56226 of 56363
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Y MAP: a pipeline for visualization of copy number variation and loss of heterozygosity in eukaryotic pathogens
(BioMed Central Ltd, 2014-11)The design of effective antimicrobial therapies for serious eukaryotic pathogens requires a clear understanding of their highly variable genomes. To facilitate analysis of copy number variations, single nucleotide polymorphisms ... -
Y-family DNA polymerases in Escherichia coli
(Elsevier, 2007-01)The observation that mutations in the Escherichia coli genes umuC+ and umuD+ abolish mutagenesis induced by UV light strongly supported the counterintuitive notion that such mutagenesis is an active rather than passive ... -
YabA of Bacillus subtilis controls DnaA-mediated replication initiation but not the transcriptional response to replication stress
(Blackwell Publishing, 2009-09)yabA encodes a negative regulator of replication initiation in Bacillus subtilis and homologues are found in many other Gram-positive species. YabA interacts with the β-processivity clamp (DnaN) of DNA polymerase and with ... -
Yangians versus minimal W-algebras: A surprising coincidence
(World Scientific Pub Co Pte Lt, 2021)© 2020 World Scientific Publishing Company. We prove that the singularities of the R-matrix R(k) of the minimal quantization of the adjoint representation of the Yangian Y of a finite dimensional simple Lie algebra are the ... -
YAP Enhances Tumor Cell Dissemination by Promoting Intravascular Motility and Reentry into Systemic Circulation
(American Association for Cancer Research (AACR), 2020)The oncogene YAP has been shown previously to promote tumor growth and metastasis. However, how YAP influences the behavior of tumor cells traveling within the circulatory system has not been as well explored. Given that ... -
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth
(EMBO, 2018-10)The Hippo pathway and its nuclear effector Yap regulate organ size and cancer formation. While many modulators of Hippo activity have been identified, little is known about the Yap target genes that mediate these growth ... -
Yard Crane Scheduling for container storage, retrieval, and relocation
(Elsevier BV, 2018)© 2018 Elsevier B.V. This paper introduces a novel optimization problem resulting from the combination of two major existing problems arising at storage yards in container terminals. The Yard Crane Scheduling Problem is ... -
Yard Crane Scheduling for container storage, retrieval, and relocation
(Elsevier BV, 2018)© 2018 Elsevier B.V. This paper introduces a novel optimization problem resulting from the combination of two major existing problems arising at storage yards in container terminals. The Yard Crane Scheduling Problem is ... -
Year-Long Stability of Nucleic Acid Bases in Concentrated Sulfuric Acid: Implications for the Persistence of Organic Chemistry in Venus’ Clouds
(MDPI AG, 2024-04-23)We show that the nucleic acid bases adenine, cytosine, guanine, thymine, and uracil, as well as 2,6-diaminopurine, and the “core” nucleic acid bases purine and pyrimidine, are stable for more than one year in ... -
Yeast display evolution of a kinetically efficient 13-amino acid substrate for lipoic acid ligase
(American Chemical Society, 2009-10)Escherichia coli lipoic acid ligase (LplA) catalyzes ATP-dependent covalent ligation of lipoic acid onto specific lysine side chains of three acceptor proteins involved in oxidative metabolism. Our lab has shown that LplA ... -
Yeast Display for the Identification of Peptide-MHC Ligands of Immune Receptors
(Springer US, 2022)T cells detect peptide antigens presented by major histocompatibility complex (MHC) proteins via their T cell receptor (TCR). The sequence diversity of possible antigens, with trillions of potential peptide-MHC targets, ... -
A Yeast Model of FUS/TLS-Dependent Cytotoxicity
(Public Library of Science, 2011-04)FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant ... -
Yeast Nup84-Nup133 complex structure details flexibility and reveals conservation of the membrane anchoring ALPS motif
(Springer Science and Business Media LLC, 2020)The hallmark of the eukaryotic cell is the complex endomembrane system that compartmentalizes cellular functions. Transport into and out of the nucleus occurs through the nuclear pore complex (NPC). The heptameric Nup84 ... -
Yeast Reveal a ‘Druggable’ Rsp5/Nedd4 Network That Ameliorates α-Synuclein Toxicity in Neurons
(American Association for the Advancement of Science (AAAS), 2013-10)α-Synuclein (α-syn) is a small lipid-binding protein implicated in several neurodegenerative diseases, including Parkinson’s disease, whose pathobiology is conserved from yeast to man. There are no therapies targeting these ... -
“Yes, but will it work for my patients?” Driving clinically relevant research with benchmark datasets
(Springer Science and Business Media LLC, 2020-06)Benchmark datasets have a powerful normative influence: by determining how the real world is represented in data, they define which problems will first be solved by algorithms built using the datasets and, by extension, ... -
“Yes, I’m reminded, but it doesn’t mean I’m taking them”: Experiences with Short Message Service Reminder Use in Real-time Monitoring of HIV PrEP among Young Women in Kenya
(Springer US, 2022-07-30)Abstract Adherence to oral pre-exposure prophylaxis (PrEP) is challenging, and cellular technology offers a promising opportunity for support. However, a recent randomized controlled trial found that SMS ... -
Yield Hardening of Electrorheological Fluids in Channel Flow
(American Physical Society, 2016-06)Electrorheological fluids offer potential for developing rapidly actuated hydraulic devices where shear forces or pressure-driven flow are present. In this study, the Bingham yield stress of electrorheological fluids with ... -
Yield precursor in primary creep of colloidal gels
(Royal Society of Chemistry (RSC), 2022-10-12)<jats:p>Colloidal gels under moderate stress show an early precursor to yield detectable at macroscopic length scales. This precursor arises from accumulation of local plastic events.</jats:p>