Browsing MIT Open Access Articles by Title
Now showing items 4837-4856 of 56319
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C 14 H 10 polycyclic aromatic hydrocarbon formation by acetylene addition to naphthalenyl radicals observed
(Royal Society of Chemistry (RSC), 2021)<p>Primary reaction pathways for 2-naphthalenyl + acetylene predicted by the kinetic model under the experimental conditions in this work.</p> -
c-Jun N-terminal kinase in synergistic neurite outgrowth in PC12 cells mediated through P90RSK
(BioMed Central Ltd, 2013-12)Background: Synergistic multi-ligand treatments that can induce neuronal differentiation offer valuable strategies to regulate and modulate neurite outgrowth. Whereas the signaling pathways mediating single ligand-induced ... -
C-LEARN: Learning geometric constraints from demonstrations for multi-step manipulation in shared autonomy
(Institute of Electrical and Electronics Engineers (IEEE), 2017-06)Learning from demonstrations has been shown to be a successful method for non-experts to teach manipulation tasks to robots. These methods typically build generative models from demonstrations and then use regression to ... -
c-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification
(American Association for Cancer Research (AACR), 2018-03)The amplified MYCN gene serves as an oncogenic driver in approximately 20% of high-risk pediatric neuroblastomas. Here, we show that the family member MYC is a potent transforming gene in a separate subset of high-risk ... -
c-Myc regulates transcriptional pause release
(Elsevier, 2010-04)Recruitment of the RNA polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA-binding transcription factors is well recognized as a key regulatory step in gene expression. We report here ... -
C-Parameter Distribution at N[superscript 3]LL′ Including Power Corrections
(American Physical Society, 2015-05)We compute the e[superscript +]e[superscript -] C-parameter distribution using the soft-collinear effective theory with a resummation to next-to-next-to-next-to-leading-log prime accuracy of the most singular partonic ... -
The C-Terminal Domain of Eukaryotic Initiation Factor 5 Promotes Start Codon Recognition by Its Dynamic Interplay with eIF1 and eIF2β
(Elsevier, 2012-05)Recognition of the proper start codon on mRNAs is essential for protein synthesis, which requires scanning and involves eukaryotic initiation factors (eIFs) eIF1, eIF1A, eIF2, and eIF5. The carboxyl terminal domain (CTD) ... -
C. elegans discriminates colors to guide foraging
(American Association for the Advancement of Science (AAAS), 2021-03)Color detection is used by animals of diverse phyla to navigate colorful natural environments and is thought to require evolutionarily conserved opsin photoreceptor genes. We report that Caenorhabditis elegans roundworms ... -
C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability
(Elsevier, 2010-12)DNA replication and its connection to M phase restraint are studied extensively at the level of single cells but rarely in the context of a developing animal. C. elegans lin-6 mutants lack DNA synthesis in postembryonic ... -
The C. elegans MicroRNA mir-71 Acts in Neurons to Promote Germline-Mediated Longevity through Regulation of DAF-16/FOXO
(Elsevier, 2012-04)The life span of Caenorhabditis elegans is controlled by signaling between the germline and the soma. Germ cell removal extends life span by triggering the activation of the DAF-16/FOXO transcription factor in the intestine. ... -
C. elegans Notch Signaling Regulates Adult Chemosensory Response and Larval Molting Quiescence
(Elsevier B.V., 2011-05)Background: The conserved DOS-motif proteins OSM-7 and OSM-11 function as coligands with canonical DSL (Delta, Serrate, and LAG-2) ligands to activate C. elegans Notch receptors during development. We report here that ... -
C21orf57 is a human homologue of bacterial YbeY proteins
(Elsevier, 2017-01)The product of the human C21orf57 (huYBEY) gene is predicted to be a homologue of the highly conserved YbeY proteins found in nearly all bacteria. We show that, like its bacterial and chloroplast counterparts, the HuYbeY ... -
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
(American Association for the Advancement of Science (AAAS), 2016-08)The clustered regularly interspaced short palindromic repeat (CRISPR)–CRISPR-associated genes (Cas) adaptive immune system defends microbes against foreign genetic elements via DNA or RNA-DNA interference. We characterize ... -
C4: Verified Transactional Objects
(ACM, 2022-04-29) -
C7-Derivatization of C3-Alkylindoles Including Tryptophans and Tryptamines
(American Chemical Society (ACS), 2014-10)A versatile strategy for C7-selective boronation of tryptophans, tryptamines, and 3-alkylindoles by way of a single-pot C2/C7-diboronation–C2-protodeboronation sequence is described. The combination of a mild iridium-catalyzed ... -
C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly
(Wiley, 2019-07-28)Ragulator is a pentamer composed of p18, MP1, p14, C7orf59, and hepatitis B virus X-interacting protein (HBXIP; LAMTOR 1—5) which acts as a lysosomal scaffold of the Rag GTPases in the amino acid sensitive branch of TORC1 ... -
A C9orf72 ALS/FTD Ortholog Acts in Endolysosomal Degradation and Lysosomal Homeostasis
(Elsevier BV, 2018-05)The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the expansion of a hexanucleotide repeat in a non-coding region of the gene C9orf72. We report that loss-of-function ... -
A C[subscript 2]-symmetric, basic Fe(iii) carboxylate complex derived from a novel triptycene-based chelating carboxylate ligand
(Royal Society of Chemistry, The, 2012-06)A triptycene-based bis(benzoxazole) diacid ligand H[subscript 2]L2[superscript Ph4] bearing sterically encumbering groups was synthesized. Treatment of H[subscript 2]L2[superscript Ph4] with Fe(OTf)[subscript 3] afforded ... -
C[subscript 3], semi-clifford and generalized semi-clifford operations
(Rinton Press, 2010-01)Fault-tolerant quantum computation is a basic problem in quantum computation, andteleportation is one of the main techniques in this theory. Using teleportation on stabi-lizer codes, the most well-known quantum codes, Pauli ... -
C[superscript ∞] Scaling Asymptotics for the Spectral Projector of the Laplacian
(Springer US, 2017-05)This article concerns new off-diagonal estimates on the remainder and its derivatives in the pointwise Weyl law on a compact n-dimensional Riemannian manifold. As an application, we prove that near any non-self-focal point, ...
